LYMPHOID NEOPLASIA Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia
نویسندگان
چکیده
1Section of Haemato-Oncology, The Institute of Cancer Research, Surrey, United Kingdom; 2Medical Oncology Unit, Cancer Research UK, London, United Kingdom; 3Academic Unit of Paediatric Oncology, University of Manchester, Teenage Cancer Trust Oncology Unit, Christie Hospital National Health Service Trust, Manchester, United Kingdom; 4University of Tennessee at Chattanooga and T. C. Thompson Children’s Hospital, Chattanooga; 5Dutch Childhood Oncology Group, The Hague, The Netherlands; 6Centro Ricero Tettamanti, Clinica Pediatrica University di Milano Bicocca, Monza, Italy; 7Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom; 8Children’s Hospital for Wales, Cardiff, United Kingdom; and 9Camelia Botnar Laboratories, Great Ormond Street Hospital, London, United Kingdom
منابع مشابه
LYMPHOID NEOPLASIA Brief report Discordance of MLL-rearranged (MLL-R) infant acute lymphoblastic leukemia in monozygotic twins with spontaneous clearance of preleukemic clone in unaffected twin
Concordance of MLL-rearranged acute leukemia in infant monozygotic twins is thought to be 100% with a very short latency period, suggesting that either the MLL fusion itself is sufficient to cause leukemia or that it promotes the rapid acquisition of additional oncogenic events that result in overt disease. We report the first case of discordance in an infant monozygotic twin pair. Twin A prese...
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متن کاملDiscordance of MLL-rearranged (MLL-R) infant acute lymphoblastic leukemia in monozygotic twins with spontaneous clearance of preleukemic clone in unaffected twin.
Concordance of MLL-rearranged acute leukemia in infant monozygotic twins is thought to be 100% with a very short latency period, suggesting that either the MLL fusion itself is sufficient to cause leukemia or that it promotes the rapid acquisition of additional oncogenic events that result in overt disease. We report the first case of discordance in an infant monozygotic twin pair. Twin A prese...
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